This course covers the advanced principles, concepts, and operations of medical sensors and devices. The origin and nature of measurable physiological signals are studied, including chemical, electrochemical, optical, and electromagnetic signals. The principles and devices to make the measurements, including design of electronic instrumentation, will be rigorously presented. This course will cover emerging frontiers of general diagnostics, including Electrophysical methods like ECG, EEG, EMG, defibrillator and pacemaker, imaging techniques: X-rays, nuclear medicine, ultrasound, and magnetic resonance. Supporting instrumentation like incubator, respirator, anesthesia machine and dialysis machine. Surgical techniques with diathermy and laser.