This course incorporates engineering and cellular biology principles in an effort to establish foundational understanding of structure-function relationships in normal and pathological mammalian tissues. This course will also explore the development of substitutes to restore or improve tissue and organ function. Concepts to be taught include cryobiology, stem and progenitor cell technologies and regenerative medicine applications. The students knowledge will then be applied to various clinical cases via quizzes. The students will be assessed using assignments, one laboratory exercise, an in-course test and an oral presentation.